May 4, 2020

The University of Pittsburgh announced that Pitt innovators were issued 10 U.S. patents in April 2020.

Featured Patent: “10,631,792: “System and Method of Determining a Susceptibility to Cardiorespiratory Insufficiency”

The COVID-19 pandemic has resulted in a sharp increase in patients suffering respiratory distress that require interventions, including mechanical ventillation in the most serious cases. Identification of cardiorespiratory insufficiency early or predicting its development beforehand is a challenge that leaves clinicians scrambling to respond to the rapid onset of life-threatening symptoms.

Michael Pinsky, professor of critical care medicine, and colleagues have applied machine learning principles, coupled with human physiological data, to predict if and when patients are likely to develop future distress prior to the onset of severe symptoms, and determine which additional biomarkers and measuring frequency will improve the accuracy and specificity of these predictions. The invention can also assess whether the patient is responsive to interventions and  determine if resuscitation has effectively restored tissue oxygen perfusion.

For more information on this innovation, including licensing, contact George Coulston at

Below is a list of all patents issued to Pitt innovators in April 2020. To search the database of all Pitt innovations available for licensing, click here.

Title   Inventor(s)   Licensing Manager        Status
10,611,788 Catalytic Glycosylation With Designer Thioglycoside and Novel Protecting Groups for Same and for Synthesis of Oligosaccharides Xinyu Liu George Coulston Available for Licensing
10,610,661 Noninvasive, Regional Brain Thermal Stimuli for the Treatment of Migraine Eric Nofzinger Janice Panza Licensed
10,618,914 6-Aryl-7-Substituted-3-(1H-Pyrazol-5-YL)-7H-[1,2,4] Triazolo [3,4-B][1,3,4]Thiadizaines as Inhibitors of the STAT3 Pathway With Anti-Proliferative Activity Donna Huryn; Peter Wipf; Jennifer Grandis; Matthew LaPorte; Paul Johnston; Mark Schurdak; Raffaele Colombo Maria Vanegas Available for Licensing
10,624,737 Artificial Valved Conduits for Cardiac Reconstructive Procedures and Methods for Their Production Masahiro Yoshida; Doug Bernstin; Onur Dur; Kerem Pekkan Janice Panza Licensed
10,627,403 Activation of Myeloid-Derived Suppressor Cells as a Predictor of Patient Response to Interferon-A Therapy Larisa Geskin; Oleg Akilov Andrew Remes Available for Licensing
10,626,071 Class of HDAC Inhibitors Expands the Renal Progenitor Cells Population and Improves the Rate of Recovery From Acute Kidney Injury Neil Hukriede; Billy Day Maria Vanegas Optioned
10,631,792 System and Method of Determining a Susceptibility to Cardiorespiratory Insufficiency Michael Pinsky George Coulston Available for Licensing
10,634,686 Biomarkers Related to Organ Function John Kellum Jr.; Paulo Fontes Alex Ducruet Available for Licensing
10,633,370 Phenyl Indole Allosteric Inhibitors of P97 ATPASE Donna Huryn; Peter Wipf; Matthew LaPorte; Michelle Arkin; Jeff Neitz; Stacie Bulfer; Clifford Bryant; William Moore; Neal Green; Raffaele Colombo; Marina Kovaliov; Chaemin Lim; Celeste Alverez; Zhizhou Yue; Lalith Samahkumara; Alexander Chatterley; Yongzhao Yan; Mary Liang; Kean-Hooi Ang; Eric Baldwin Maria Vanegas Available for Licensing
10,634,756 MRI Phantom Including Hollow Fluid Filled Tubular Textiles for Calibrated Anisotropic Imaging Anthony Zuccolotto; Walter Schneider; John Dzikiy; Lee Basler; Rich Shaffer Robert Racunas Available for Licensing