January 10, 2019

The University of Pittsburgh announced that Pitt innovators were issued six patents in December 2018.

Featured Patent: U.S. 10,160,974 “Engineered Cytokne and Chemokine-Expressing Candida Albicans Strains and Methods of Use”

A team led by Sarah Gaffen, professor of rheumatology, has genetically modified strains of Candida albicans (C. albicans) to express  heterologous cytokine or chemokine proteins.  The engineered C.  albicans strains can be used to prevent or limit candidiasis such as oropharyngeal candidiasis (OPC, thrush).  OPC is an opportunistic infection associated with T cell immunodeficiency, caused mainly by the commensal C. albicans.  OPC is common in HIV/AIDS, chemotherapy, infants and the elderly, and certain congenital immunodeficiency diseases. C. albicans also causes disseminated candidiasis, which is the 4thmost common cause of hospital-acquired infections and has a 40% mortality rate.   For more information on this innovation, including licensing, contact Maria Vanegas at mvanegas@innovation.pitt.edu.


Below is a list of all patents issued to Pitt innovators in December 2018. To search the database of all Pitt innovations available for licensing, click here.

Title   Inventor(s)   Licensing Manager      Status
10,149,607 Steerable, Follow the Leader Device Alon Wolf; Marco Zenati; Howard Choset Janice Panza Licensed
10,156,479 Spatial-Domain Low-Coherence Quantitative Phase Microscopy Yang Liu; Randall Brand; Hoa Pham; Shikhar Fnu Abhishek Sangal Available for Licensing
10,160,705 Class of HDAC Inhibitors Expands the Renal Progenitor Cells Population and Improves the Rate of Recovery From Acute Kidney Injury Neil Hukriede; Billy Day Maria Vanegas Available for Licensing
10,159,674 Benzathine Analogs Beibei Chen; Rama Mallampalli Maria Vanegas Licensed
10,160,974 Engineered Cytokine and Chemokine-Expressing Candida Albicans Strains and Methods of Use Sarah Gaffen; Mandy McGeachy; Anna Huppler; Aaron Mitchell Maria Vanegas Available for Licensing
10,160,959 A TRPV1 Modulatory Gene Product that Affects TRPV1-Specific Pain Behavioral Responses Identified in a Functional Screen of an HSV-Based CDNA Library William Goins; Joseph Gloriorso; Justus Cohen; Bonnie Reinhart Maria Vanegas Licensed