A modeling system to predict the progression of disease outbreaks. Epistemix is based on the research of Donald Burke, former dean of the Pitt Graduate School of Public Health, and John Grefenstette, former professor of Biostatistics and Health Policy and Management. Burke and Grefenstette and their colleagues began developing FRED (Framework for Reconstructing Epidemiological Dynamics) a decade ago as a modeling system to predict the progression of disease outbreaks.