April 2, 2020

The University of Pittsburgh announced that Pitt innovators were issued 14 U.S. patents in March 2020.

Featured Patent: U.S. 10,547,376: “Layer by Layer Coated Mesh for Local Release of Bioactive Proteins”

The host immune response to therapeutic implants can cause severe complications. By applying a new active agent-eluting coating to implantable biomaterials, researchers are able to modulate the local immune reaction and reduce implant-related complications and /or improved integration of the biomaterial into the host tissue. The active agent-eluting coating can be applied to impolanted materials such as mesh, sutures, wound dressings, intraocular lenses, decellularized matrices, bone plates, joint replacements, biosensors, catheters, pacemakers, artificial organs, stents, ventricular assist devices, and neural electrodes, among others, to mitigate the inflammatory reaction to the implant and promote better implant integration into the host tissue.

For more information on this technology, including licensing, contact Janice Panza at jpanza@innovation.pitt.edu.

Below is a list of all patents issued to Pitt innovators in March 2020. To search the database of all Pitt innovations available for licensing, click here.

Title   Inventor(s)   Licensing Manager        Status
10,547,376 Layer by Layer Coated Mesh for Local Release of Bio-Active Proteins Daniel Hachim; Bryan Brown Janice Panza Available for Licensing
10,575,723 Mapping of Internal Features on En Face Imagery Lawrence Kagemann Jr.; Joel Schuman; Sayoko Moroi Janice Panza Available for Licensing
10,576,115 Oncolytic HSV Vectors Joseph Glorioso; Hioaki Uchida; Justus Cohen; Paola Grandi Maria Vanegas Licensed
10,576,051 Nitrated-Fatty Acids Modulation of Type II Diabetes Bruce Freeman; Francisco Schopfer Andrew Remes Licensed
10,582,996 Biodegradable Vascular Grafts Yadong Wang Janice Panza Available for Licensing
10,582,995 Intra-Oral Prostheses and Other Anatomical Prostheses Neil Gildener-Leapman; Youngjae Chun Janice Panza Available for Licensing
10,583,004 Retrievable Self-Expanding Non-Thrombogenic Low-Profile Percutaneous Atrioventricular Valve Prosthesis Youngjae Chun; Vinay Badhwar; William Wagner; Antonio D’Amore; David Schwartzman Janice Panza Available for Licensing
10,589,002 Biodegradable, Thermally Responsive Injectable Hydrogel for Treatment of Ischemic Cardiomyopathy Tomo Yoshizumi; William Wagner; Yang Zhu; Hongbin Jiang Janice Panza Available for Licensing
10,588,853 Custom Designed Microbubble Contrast Agents and Techniques of Ultrasound Andy Carson; Flordeliza Villanueva; Charles McTiernan; Jianjun Wang Abhishek Sangal Available for Licensing
10,596,237 Identification of Pneumocystis Antigens and Uses Thereof Jay Kolls; Michael Zheng; Yang Cai; David Ricks; Taylor Eddens Maria Vanegas Available for Licensing
10,596,197 Red Blood Cell Membrane-Derived Microparticles and Their Use for the Treatment of Lung Disesase Janet Lee Maria Vanegas Available for Licensing
10,603,156 Biodegradable Vascular Grafts Robert Allen; Chelsea Stowell; Yadong Wang Janice Panza Available for Licensing
10,604,827 Biodegradable Metal Alloys Da-Tren Chou; Partha Saha; Dae Ho Hong; Prashant Kumta Janice Panza Available for Licensing
10,603,321 Small Molecules Targeting HIV-1 NEF Thomas Smithgall Andrew Remes Available for Licensing