November 11, 2020

The University of Pittsburgh announced that Pitt innovators were issued seven U.S. patents in October 2020.

Featured Patent: 10,815,457Active CXCR4+ Immune Cells and Methods for Their Production and Use

Pitt Innovators have developed a Trojan Horse-like method of following tumor pathways to kill cancer cells. Effectiveness of immunity depends on proper homing of subsets of T cells to different tissues. The ability of cytotoxic CD8+ effector T cells to migrate to tumor and chronically-inflamed tissues is critical for their ability eliminate cancer cells and intracellular infections. The induction of CXCR4 on killer cells could allow them to exploit the pathway used by the tumors to attract suppressive cells, and instead to enter tumors and kill cancer cells.The cells described by the innovators are simple to generate and require only low-cost procedures or reagents

For more information on this innovation, including licensing, contact Andrew Remes at

Below is a list of patents issued to Pitt innovators in October 2020. To search the database of all Pitt innovations available for licensing, click here.


Title   Inventor(s)   Licensing Manager        Status
10,801,982 Graphic Carbon Nitride Sensors James Ellis; Alexander Star George Coulston Available for licensing
10,806,757 Biologic Scaffold For Prevention of Pulmonary Fibrosis Thomas Gilbert; Tim Oury; Michelle Manni Andrew Remes Licensed
10,811,835 Laser System Enabled by Additive Manufacturing Shuo Li; Peng Kevin Chen; Albert Chi Fu To George Coulston Available for Licensing
10,806,586 Biomimetic Rotated Lamellar Plywood Motifs of Metal Alloy Scaffolds by Additive Manufacturing for Bone Tissue Engineering Prashant Kumta; Gary Zhengbo Yu; Abhijit Roy Janice Panza Available for Licensing
10,813,915 Promoting Sleep Using AT1 Receptor Blockers Georgina Cano; Alan Sved Maria Vanegas Available for licensing
10,815,457 Active CXCR4+ Immune Cells and Methods for Their Production and Use Pawel Kalinski; Ravikumar Muthuswamy Andrew Remes Available for licensing
10,813,549 Optical Coherence Tomography as a Rapid, Accurate, Non-Contact Method of Visualizing the Palisades of Vogt Kira Lathrop; Lawrence Kageman Jr.; Joel Schuman Janice Panza Available for licensing