March 9, 2020

The University of Pittsburgh announced that Pitt innovators were issued seven  U.S. patents in February 2020.

Featured Patent: “U.S. 10,568,886: Targeting Cyt5R3”

Adam Straub, associate professor of pharmacology and chemical biology, and colleagues, have discovered that CyB5R3 is a novel therapeutic target to increase cGMP signaling in cells. Based on this discovery, the researchers have identified novel small molecule inhibitors of CyB5R3 that may have potential therapeutic applications in different disease areas. These compounds can be used as vasoconstrictors and may be treating massive hemoptysis (airway bleeding), GI bleeding, epistaxis (nosebleeds), migraine headaches, acute musculoskeletal injuries and trauma, intraoperative bleeding, uterine hemorrhage and menorrhagia, septic shock, and anaphylactic shock and allergies. Additionally, these compounds can also act as vasodilators to achieve local vasodilation for treating diseases such as erectile dysfunction, myocardial infarctions (heart attacks), musculoskeletal/sports injuries, Raynaud’s disease, hypertension, diabetic vasculopathy, and cardiogenic shock.

For more information on this technology, including licensing, contact Abhishek Sangal  at

Below is a list of all patents issued to Pitt innovators in February 2020. To search the database of all Pitt innovations available for licensing, click here.

Title   Inventor(s)   Licensing Manager        Status
10,549,022 Extracorporeal Gas Exchange Devices, Systems and Methods Richard Jeffries; William Federspiel; Brian Frankowski Maria Vanegas Available for Licensing
10,577,856 Biomarkers of Renal Injury Kai Singbartl; John Kellum Jr. Alex Ducruet Licensed
10,564,143 Methods and Apparatus to Measure Constitutive Relations and Fiber Orientation of Soft Tissues Kang Kim; Choon Yap Abhishek Sangal Available for Licensing
10,561,710 Goblet Cell Replacement Therapy Cecelia Yates-Binder; Alan Wells; Joel Schuman; Ian Connor Janice Panza Licensed
10,562,940 Computationally Optimized Broadly Reactive Antigens for H1N1 Influenza Corey Crevar; Ted Ross Andrew Remes Licensed
10,568,886 Targeting CtyB5R3 Adam Straub; Carlos Camacho; Mizanur Rahaman; Fabio Reinders Abhishek Sangal Available for Licensing
10,570,460 Fusion Genes Associated with Progressive Prostate Cancer Jianhua Luo; Yanping Yu; Joel Belson; George Michalopoulos; Chien-Cheng Tseng; Ying Ding Andrew Remes Available for Licensing