Pitt innovators were issued four patents in April 2022.
Featured patent: 11,298,409 Mutant Huntingtin-Mediated Protein Dysfunction
Huntington’s Disease is a neurodegenerative disease characterized by progressive neurological dysfunction and selective neuronal loss caused by a mutation in the gene that produces the protein huntingtin. Robert Friedlander, the Walter E. Dandy Professor and Chairman, University of Pittsburgh Department of Neurological Surgery, and colleagues have identified an interaction between mutant huntingtin (muHtt) protein and a mitochondrial transport protein complex TIM23. The investigators demonstrated that binding of muHtt to TIM23 inhibits mitochondrial protein import. This results in mitochondrial dysfunction, which leads to neuronal dysfunction and cell death. The malfunction occurs very early in the development of Huntington’s Disease, making it an attractive therapeutic target. Researchers successfully attenuated the import defect and subsequent neuronal death, as well as significantly restored mitochondrial activity by overexpression of TIM23 subunits.
This work carries significant implications for protein import-based gene therapies in the treatment of Huntington’s Disease.
For more information on this technology, including licensing, contact Maria Vanegas at email@example.com.
Below is a listing of all patents issued to Pitt innovators in April 2022.
|11,291,688||Extracellular Matrix Hydrogel and Soluble Fraction Thereof for the Treatment of Cancer||Stephen Badylak; George Hussey; Mark Murdock; Lindsey Saldin||Alex Ducruet||Licensed|
|11,298,423||Protection and Delivery of Multiple Therapeutic Proteins||Daniel Long; Noah Johnson; Eric Jeffries; Yadong Wang||Janice Panza||Available for Licensing|
|11,298,409||Mutant Huntingtin-Mediated Protein Dysfunction||Robert Friedlander; Hiroko Yano||Maria Vanegas||Available for Licensing|
|11,298,417||Measles Virus Vaccine Expressing SARS-COV-2 Proteins||William Paul Duprex; Natasha Louise Tilston-Lunel; Shamkumar Nambulli||Alex Ducruet||Available for Licensing|