January 20, 2020
The University of Pittsburgh announced that Pitt innovators were issued 16 U.S. patents in December 2020.
Featured Patent: 10,851,354 “TRPV1Modulatory Gene Product That Affects TRPV1-Specific Pain Behavioral Responses Identified in a Functional Screen of an HSV-Based cDNA Library”
Using herpes simplex virus (HSV) gene vectors, Pitt researchers from the lab of Joseph Glorioso, professor of microbiology and molecular genetics, were able to screen for and isolate a specific gene that can target pain-related behaviors associated with TRPV1, a gene implicated in the chronic pain state of patients with arthritis, cancer, cystitis, diabetic neuropathy, and post-herpetic neuralgia. Excitingly, the gene product is highly specific for TRPV1 and does not affect genes TRPM8 or TRPA1, which are involved in a variety of important responses including touch, cold, and other sensations that are undesirable to alter. This technology has broad and flexible applicability for the treatment of disease and associated chronic pain.
For more information on this innovation, including licensing, contact Maria Vanegas at firstname.lastname@example.org.
Below is a list of patents issued to Pitt innovators in December 2020. To search the database of all Pitt innovations available for licensing, click here.
|10,849,667||Biodegradable, Magnesium-Containing Bone Screws, Methods for Their Preparation and Medical Applications Thereof||John Holmes; Alejandro Almarza; William Chung; Sarah Henderson||Janice Panza||Available for licensing|
|10,849,519||Wearable Cardiac Electrophysiology Measurement Devices, Software, Systems and Methods||Matthew Jones; George Mendenhall||Janice Panza||Licensed|
|10,851,354||TRPV1Modulatory Gene Product That Affects TRPV1-Specific Pain Behavioral Responses Identified in a Functional Screen of an HSV-Based cDNA Library||William Goins; Joseph Glorioso; Justus Cohen; Bonnie Reinhart||Maria Vanegas||Available for Licensing|
|10,851,153||Compositions and Methods for the Treatment of Carboxyhemoglobinem||Jesus Bravo; Mark Gladwin||Maria Vanegas||Licensed|
|10,857,112||Small Molecule Inhibitors of RNA Binding Motif (RBM) Proteins for the Treatment of Acute Cellular Injury||Travis Jackson; Jonathan Verrier; Patrick Kochanek||Maria Vanegas||Available for licensing|
|10,858,381||Antioxidant Compounds and Their Use||Noah Snyder; Xinyan Cui; Kasey Catt; James Eles||Janice Panza||Licensed|
|10,876,041||Carbon Dioxide and Polymer Compositions for Permeability Control and Sealing||Robert Enick||Janice Panza||Available for licensing|
|10,864,234||Stem Cell-Based Technologies for Avian Skeletal Tissue Engineering and Regeneration||Rocky Tuan||Janice Panza||Available for Licensing|
|10,865,228||Computationally Optimized Broadly Reactive Antigens||Ted Ross; Corey Crevar; Brendan Giles||Andrew Remes||Licensed|
|10,869,629||Deep Learning for Classification of Swallows||Ervin Sejdic; James Coyle; Amro El-Jaroudi; Zhi-Hong Mao; Mingui Sun||Janice Panza||Available for Licensing|
|10,869,866||Benzathine Analogs||Beibei Chen; Rama Mallampalli||Maria Vanegas||Licensed|
|10,870,918||Synthesis of Structured Carbon Material From Organic Materials||Feng Zhou; Haitao Liu||George Coulston||Available for Licensing|
|10,869,850||Nitrated-Fatty Acids Modulation of Type II Diabetes||Bruce Freeman; Francisco Schopfer||Andrew Remes||Licensed|
|10,874,730||Interleukin-13 Receptor Alpha2 Peptide-Based Cancer Vaccines||Hideho Okada||Alex Ducruet||Licensed|
|10,876,111||Methods and Materials for Cloning Functional T Cell Receptors From Single T Cells||Adriana Neves; Mark Shlomchik; Eduardo Neves; Constantinos Panousis; Alexander Rowe||Jeffrey Depp||Licensed|
|10,878,977||Compositions Including Nano-Particles and a Nano-Structured Support Matrix and Methods of Preparation as Reversible High Capacity Anodes in Energy Storage Systems||Prashanth Hanumantha; Prashant Kumta; Bharat Gattu; Wei Wang||Janice Panza||Available for Licensing|